Autoinducer and environmental amphiphilicity

Reggie Du

Bacteria use amphiphilic autoinducers to control quorum sensing.  Bacterial membranes and the biofilm matrix have an amphiphilic structure, meaning they contains both hydrophilic and hydrophobic domains. We hypothesize that, by sequestering amphiphilic autoinducers used by the bacteria to control quorum sensing, amphiphilic environmental structure can influence the gene expression of bacteria. This work is done in collaboration with the lab of Professor Stephen Trent in Molecular Biosciences at University of Texas, Austin.