Molecular motor proteins are crucial for the proper
distribution of organelles and vesicles in cells.
Much of our current understanding of how motors
function stems from studies of single motors moving
cargos in vitro. More recently, however, there has
been mounting evidence that the cooperation of
multiple motors in moving cargos and the regulation
of motor’filament affinity could be key mechanisms
that cells utilize to regulate cargo transport. Here, we
review these recent advances and present a picture
of how the different mechanisms of regulating the
number of motors moving a cargo could facilitate
cellular functions.