Cytotoxic T cells accomplish their task through the localized secretion of molecules that kill tumor and virus-infected cells. The entire process is largely orchestrated by the molecular motor protein dynein that carries cargo (secretory vesicles) along microtubules towards the microtubule organizing center (MTOC; see green labeled structures in the image). We will present evidence that there are two separate dynein complexes that join forces to deliver secretory vesicles to the target cell.