Rasika Harshey
Molecular Genetics and Microbiology and Institute of Cellular and Molecular Biology, UT Austin
Cell density and mobility protect swarming bacteria against antibiotics
Swarming bacteria move in multicellular groups and exhibit adaptive resistance to multiple
antibiotics. Analysis of this phenomenon has revealed the protective power of high cell
densities to withstand exposure to otherwise lethal antibiotic concentrations. We find that
high densities promote bacterial survival, even in a nonswarming state, but that the ability
to move, as well as the speed of movement, confers an added advantage, making swarming an
effective strategy for prevailing against antimicrobials. We find no evidence of induced
resistance pathways or quorum sensing mechanisms controlling this group resistance, which
occurs at a cost to cells directly exposed to the antibiotic. This work has relevance to
the adaptive antibiotic resistance of bacterial biofilms.